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KMID : 0608520030090010157
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Korean Journal of Oriental Medicine
2003 Volume.9 No. 1 p.157 ~ p.178
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Effects of Chengwhabosimtang on depression, anxiety, TH and c-Fos of the brain in the CMS treated rats
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조충훈
신현규/황의안
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Abstract
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Objective: This study was designed to assess the protective effects of Chengwhabosimtang on the animal model of depression, chronic mild stress(CMS).
Method: Male Sprague-Dawley rats Were used for this experiment. The subjects Were divided into 3 groups (1. CMS-drug: Chengwhabosimtang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment they were executed Forced swimming test(FST) and Elevated plus maze. Tyrosine hydroxylase(TH) in ventral tegmental area(VTA) and c-Fos in paraventricular nucleus(PVN) Were measured.
Result:
1. In FST, CMS-drug group showed significantly decreased immobility behavior.
2. CMS-drug group showed uo significantly lower TH level in VTA than CMS-vehicle group.
3. CMS-drug group showed significantly less c-Fos expressed cell bodies in PVN than CMS-vehicle group.
4. In Elevated plus maze, CMS-drug group showed no significantly anxiety.
Conclusion: These results suggest that Chengwhabosimtang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus and dopaminergic neurons in VTA.
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KEYWORD
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